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Peer-Reviewed Publications (*Haverford student):
- Been, L.E., Halliday, A.R.*, Blossom, S.M.*, Bien, E.M.*, Bernhard, A.G. *, Roth, G.E.*, Domenech Rosario, K.I.*, Pollack, K.B.*, Abramenko, P.E.*, Behbehani, L.M.*, Pascal, G.J.*, and Kelly, M.E. Long-term oral Tamoxifen administration decreases Brain-Derived Neurotrophic Factor in the hippocampus of female Long-Evans rats. (2024) Cancers, 16(7), 1373.
- Irvine, A.*, Gaffney, M.*, Haughee, E, Horton, M.*, Morris, H.*, Harris, K.*, Corbin, J.*, Merrill, C.*, Perlis, M., and Been, L.E. Elevated estradiol during a hormone simulated pseudopregnancy decreases sleep and increases hypothalamic activation in female Syrian hamsters. (2023) Journal of Neuroendocrinology, 35(7): e13278.
- Foster, W.B.*, Beach, K.F.*, Carson, P.F.*, Harris, K.C.*, Alonso, B.L.*, Costa, L.T.*, Simamora, R.C.*, Corbin, J.E.*, Hoag, K.F.*, Mercado, S.I.*, Bernhard, A.G.*, Leung, C.H., Nestler, E.J. and Been, L.E. Estradiol withdrawal following a hormone simulated pregnancy induces deficits in affective behaviors and increases ∆FosB in D1 and D2 neurons in the nucleus accumbens core in mice. (2023) Hormones and Behavior, 149, 105312.
- Been, L.E., Sheppard, P.A.S., Galea, L.A.M., and Glasper, E.R. Hormones and Neuroplasticity: A Lifetime of Adaptive Responses. (2022) Neuroscience and Biobehavioral Reviews, 132, 679-690.
- Hedges, V.L, Heaton, E.C.*, Amaral-Marrero, C.F.*, Benedetto, L.E.*, Bodie, C.L.*, D’Antonio, B.I.*, Davila, D.R.*, Lee, R.H.*, Levine, M.T.*, O’Sullivan, E.C.*, Pisch, N.P.*, Taveras, S.*, Wild, H.R.*, Grieb, Z.A., Ross, A.P., Albers, H.E., and Been, L.E. (2021) Estrogen withdrawal alters oxytocin plasticity in the paraventricular hypothalamus and dorsal raphe nucleus to increase postpartum anxiety. Biological Psychiatry, 89(9): 929-938.
- Moore, K.M., Oelberg, W.L., Glass, M.R.*, Johnson, M.D., Been, L.E., and Meisel, R.L. (2019) Glutamate afferents from the medial prefrontal cortex mediate nucleus accumbens activation by female sexual behavior. Frontiers in Behavioral Neuroscience, 113-227.
- Meisel, R.L. and Been, L.E. (2019). Dopamine. In: Encyclopedia of Sexuality and Gender, Lykins, A. (Editor), New York, Springer.
- Been, L.E., Gibbons, A.B.* and Meisel, R.L. (2019). Towards a Neurobiology of Female Aggression. Neuropharmacology, 156: 107451.
- Acaba, L.* Sidibe, D.*, Thygesen, J.* Van der Kloot, H.*, and Been, L.E. (2018). Sexual experience increases Delta FosB in the nucleus accumbens of male and female Syrian hamsters. Behavioral Neuroscience, 133(4): 378-384.
- Abbott, C.* and Been, L.E. (2017). Strategies for Transforming a Neuroscience Classroom into a Brave and Trusting Learning Environment: A Dialogic Approach. Teaching and Learning Together In Higher Education, Issue 22.
- Been, L.E., Mermelstein, P.G., and Meisel, R.L. (2016). Using a pop-science book to teach introductory neuroscience: advantages for science majors and non-science majors alike. Journal of Undergraduate Neuroscience Education, 15(1): A67-A71
- Been, L.E., Moore, K.M., Kennedy, B.C., and Meisel, R.L. (2016). Metabotropic glutamate receptors and Fragile X Signaling in a female model of escalated aggression. Biological Psychiatry, 79(8): 685-92.
- Been L.E., Staffend, N.A., Tucker, A., and Meisel, R.L. (2013). Vesicular glutamate transporter 2 and tyrosine hydroxylase are not co-localized in Syrian hamster nucleus accumbens afferents. Neuroscience Letters, 550: 41-5.
- Been, L.E., Vialou V., Hedges, V.L., Nestler, E.J., and Meisel, R.L. (2013). Delta JunD overexpression in the nucleus accumbens prevents sexual reward in female Syrian hamsters. Genes, Brain, and Behavior, 12(6):666-72.
- Been, L.E. and Petrulis, A. (2012). Dissociated functional pathways for appetitive and consummatory reproductive behaviors in male Syrian hamsters. Hormones and Behavior, 61(2): 204-211.
- Been, L.E., Bauman, J.B., Petrulis, A. and Chang, Y.H. (2012). X-ray kinematics of vaginal scent marking in female Syrian hamsters (Mesocricetus auratus). Physiology and Behavior, 105: 1021-2027.
- Been, L.E. and Petrulis, A. (2011). Chemosensory and hormone information are relayed directly between the medial amygdala, posterior bed nucleus of the stria terminalis, and medial preoptic area in male Syrian hamsters. Hormones and Behavior, 59(4): 536-548.
- Been, L.E. and Petrulis, A. (2010). The role of the medial preoptic area in appetitive and consummatory reproductive behaviors depends on sexual experience and odor volatility in male Syrian hamsters. Neuroscience, 170: 1120-1132.
- Been, L.E. and Petrulis, A. (2010). Lesions of the posterior bed nucleus of the stria terminalis eliminate opposite-sex odor preference and delay copulation in male Syrian hamsters: role of odor volatility and sexual experience. European Journal of Neuroscience, 32(3): 483-493.
- Been, L.E. and Petrulis, A. (2008). The Neurobiology of Sexual Solicitation: Vaginal Marking in Female Syrian Hamsters. In: Hurst, J.L., Benyon, R. J., Roberst, S.C., and T. Wyatt (Eds) Chemical Signals in Vertebrates XI, New York, Springer.
Other Writing and Media
- Biological Psychiatry Live! Podcast: “Estrogen withdrawal alters oxytocin plasticity in the paraventricular hypothalamus and dorsal raphe nucleus to increase postpartum anxiety,” December 2, 2020. https://www.biologicalpsychiatryjournal.com/pb/assets/raw/Health%20Advance/journals/bps/Biological_Psychiatry_Live_Dr._Been.mp4
- NIH Office of Behavioral and Social Sciences Research Featured Blog Post: “A Behavioral and Neural Model for Escalated Aggression in Females,” August 9, 2016. https://obssr.od.nih.gov/news-and-events/news/behavioral-and-neural-model-escalated-aggression-females
Selected Conference Abstracts (*Haverford student):
- Halliday, A.R.*, Blossom, S.M.*, Bien, E.*, Kelly, M.E., and Been, L.E. The effects of long-term oral Tamoxifen administration on Brain Derived Neurotrophic Factor (BDNF) expression in the hippocampus of female Long-Evans Hooded rats. Society for Neuroscience Annual Meeting, San Diego, CA, 2022.
- Clayton, E.*, Moniz, H.E.*, Craig, L.E.*, Halliday, A.R.*, and Been, L.E. Blocking estrogen receptors in the ventral tegmental area does not alter FosB Immunoreactivity in the nucleus accumbens of ovariectomized female mice. Society for Neuroscience Annual Meeting, San Diego, CA, 2022.
- Zhang, Z.*, Eaton, R.S.*, Courtney, M.Y.*, and Been, L.E., FosB immunoreactivity in the nucleus accumbens is altered by peripartum estradiol and progesterone fluctuations in female mice. Society for Neuroscience Annual Meeting, San Diego, CA, 2022.
- Simamora, R.C.*, Alonso, B.L.*, Costa, L.T.*, and Been, L.E. The impact of postpartum estrogen withdrawal following a hormone-simulated pseudopregnancy on anxiety and motivational behaviors in adult female mice. Society for Neuroscience Annual Meeting, Chicago, IL, 2021.
- Blossom, S.M.*, Halliday, A.R.*, Roth, G.*, Domenech, K.*, Abramenko, P.*, Pollack, K.*, Pascal, G.*, Behbehani, L.*, Been, L.E., and Kelly, M. The effects of long-term oral tamoxifen administration on anxiety and cognition in Long-Evans Hooded female rats: a potential role for BDNF? Society for Neuroscience Annual Meeting, Chicago, IL, 2021.
- Corbin, J.E.*, Merrill, C.*, Harris, K.C.*, Horton, M.A.*, Morris, H.C.*, Haughee, E.K., and Been, L.E.Peripartum estradiol fluctuations impact sleep actigraphy and neural plasticity during a hormone-simulated pseudopregnancy in female Syrian hamsters. Society for Neuroscience Annual Meeting, Chicago, IL, 2021.
- Roth, G.*, Been, L.E., Domenech, K.*, Pollock, K.*, Abramenko, P.*, Edwards, S., Vedar, C., Cohen, A., Moorthy, G., Zupppa, A., and Kelly, M.E. Development of a sensitive UPLC-MS/MS assay for tamoxifen: application to a rat pharmacological and behavioral study. American Society for Mass Spectrometry, Philadelphia, PA, 2021.
- Harris, K.C.*, Horton, M.A.*, Morris, H.C.*, Haughee, E.K. and Been, L.E. The impact of peripartum estrogen fluctuations on sleep actigraphy and neuroplasticity in the dorsal raphe nucleus in Syrian hamsters. Society for Behavioral Neuroscience, Atlanta, GA (remote), 2021.
- Davilla, D.R.*, O’Sullivan, E.*, Pisch, N.M.*, Wild, H.R.*, Albers, H.E., and Been, L.E. Blocking oxytocin receptors in the dorsal raphe following a hormone simulated pregnancy alters postpartum anxiety-like behavior in female Syrian hamsters. Society for Behavioral Neuroendocrinology, Bloomington, IA, 2019.
- Gibbons, A.B.*, Singh, A.K.*, Gearinger, D.R.*, Valentine, A.A.*, Nestler, E.J., and Been, L.E. Preventing the accumulation of delta FosB in the Nucleus Accumbens of female mice during a hormone-simulated pregnancy alters anxiety-like behavior. Society for Neuroscience, Chicago, IL, 2019.
- Beach, K.F.*, Carson, P.F.*, Foster, W.B.*, Nestler, E.J., and Been, L.E. Delta FosB is increased in the nucleus accumbens core of female mice following a hormone-simulated pregnancy. International Congress of Neuroendocrinology, Toronto, Canada, 2018.
- Benedetto, L.E.*, Heaton, E.C.*, Levine, M.T.*, Taveras, S.*, Ross, A.P., Albers, H.E., and Been, L.E. Estrogen withdrawal increases anxiety-like behavior and dorsal raphe oxytocin receptors in female hamsters. Parental Brain Meeting, Toronto, Canada, 2018.
- Hedges, V., Bianco, H., Friendt, T., Amaral, C.*, Bodie, C.*, D’Antonio, B.*, Lee, R.*, and Been, L.E. Estrogen withdrawal increases oxytocin in the paraventricular hypothalamus and alters open field behavior in Syrian hamsters. Society for Neuroscience, Washington, D.C., 2017.
- Foster, W.*, Heaton, E.*, and Been, L.E. Increased oxytocin immunoreactivity in the paraventricular nucleus, but not the supraoptic nucleus, following a hormone-simulated pregnancy in female Syrian hamsters. Society for Neuroscience, Washington, D.C., 2017.
- Hedges,V., Bianco, H., Friendt, T., Amaral, C*., Bodie, C.*, D’Antonio, B.*, Lee, R.*, and Been, L.E. Estrogen withdrawal increases oxytocin in the paraventricular nucleus of the hypothalamus and alters open field behavior in Syrian hamsters. Society for Neuroscience, Washington, D.C., 2017.
- Gaines, A.*, Beach, K.*, and Been, L.E. How does sex experience change neural responding in the motivational circuit? Society for Neuroscience, San Diego, CA, 2016.
- Himmler, B.T., Moore, K.M., Been, L.E., Teplitzky, B.A., and Meisel, R.L. Measuring the tonic and phasic release of dopamine during sexual behavior in female hamsters using fixed potential amperometry. Society for Neuroscience, San Diego, CA, 2016.
- Acaba, L.* Sidibe, D.*, Thygesen, J.* Van der Kloot, H.*, and Been, L. Sexual experience increases Delta FosB in the nucleus accumbens of male and female Syrian hamsters. Society for Behavioral Neuroendocrinology, Montreal, Canada, 2016.
- Glass, M.R.*, Moore, K.M., Himmler, B.T., Been, L.E., and Meisel, R.L. Visualizing nucleus accumbens afferents active during female Syrian hamster sex experience. Society for Neuroscience, Chicago, IL, 2015.
- Been, L.E., Himmler, B.T., Ebner, S.R., and Meisel, R.L. Using fast-scan cyclic voltammetry to measure dopamine release from the nucleus accumbens of female hamsters during sex behavior. Society for Neuroscience, Chicago, IL, 2015.
- Been, L.E., Moore, K.M., Kennedy, C.K., and Meisel, R.M. Aggressive experience increases PSD-95 in the nucleus accumbens of female hamsters via activation of the Fragile-X Mental Retardation Protein signaling pathway. Society for Neuroscience, Washington, DC, 2014.
- Moore, K.M, Been, L.E., Meisel, R.M. “Neurotransmitter measurement during sexual behavior in female Syrian hamsters,” Society for Neuroscience, Washington, DC, 2014.
- Moore, K.M, Been, L.E., Meisel, R.M. “Increased accumbal glutamate release during sex behavior in female hamsters.” International Congress of Neuroendocrinology, Sydney, Australia, 2014.
- Been, L.E., Moore, K.M., Kennedy, C.K., and Meisel, R.M. Aggressive experience increases PSD-95 in the nucleus accumbens of female hamsters via activation of the Fragile-X Mental Retardation Protein signaling pathway. Organization for the Study of Sex Differences, Minneapolis, MN, 2014.
- Moore, K.M, Been, L.E., Meisel, R.M. “Increased accumbal glutamate release during sex behavior in female hamsters.” Organization for the Study of Sex Differences, Minneapolis, MN, 2014.
- Been L.E., Kennedy BC, and Meisel, RL. Aggressive experience activates the Fragile X Mental Retardation Protein (FMRP) signaling pathway in the nucleus accumbens of female hamsters. Society for Neuroscience, New Orleans, LA, 2012.
- Been, L.E. and Petrulis, A. “Functionally disconnecting the medial amygdala from the medial preoptic area eliminates copulation but not odor preference in male Syrian hamsters.” Society for Neuroscience, Washington, DC, 2011.
- Been, L.E. and Petrulis, A. “Sexual odor-responsive cells in the medial amygdala and bed nucleus of the stria terminalis project to the medial preoptic area.” Society for Neuroscience, San Diego, CA, 2010.
- Been, L.E. and Petrulis, A. “Reevaluating the role of the medial preoptic area in appetitive and consummatory aspects of reproductive behavior in male Syrian hamsters.” Society for Behavioral Neuroendocrinology, Toronto, Canada, 2010.
- Been, L.E. and Petrulis, A. “The role of the medial preoptic area in opposite-sex odor preference in male Syrian hamsters.” Society for Neuroscience, Chicago, IL, 2009.
- Been, L.E. and Petrulis, A. Lesions of the posterior bed nucleus of the stria terminalis eliminate opposite-sex odor preference in sexually-naïve, but not sexually experienced, male Syrian hamsters.” Society for Behavioral Neuroendocrinology, East Lansing, MI, 2009.
- Been, L.E., and Petrulis, A. The role of the posterior bed nucleus of the stria terminalis in sexual odor preference in male Syrian hamsters. Society for Behavioral Neuroendocrinology, Groningen, Netherlands, 2008.
- Been, L.E. and Petrulis, A. The role of the posterior bed nucleus of the stria terminalis in opposite-sex odor preference and sexual odor processing. Society for Neuroscience, Washington, D.C., 2008.
- Been, L.E., Murphy, A.Z., Clancy, A.N. and Petrulis, A. Central nervous system neurons projecting to the vagina in Syrian hamsters: implications for vaginal marking. Society for Behavioral Neuroendocrinology, Pacific Grove, CA, 2007.
- Been, L.E. and A. Petrulis. The neurobiology of sexual solicitation: vaginal marking in female Syrian hamsters. Chemical Signals in Vertebrates XI, Chester, UK, 2006.
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